HOW MUCH YOU NEED TO EXPECT YOU'LL PAY FOR A GOOD PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation aspect eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to unique stimuli12, triggering the integrated tension